|
Maria Lajer
Research fellow
Education
| 1995 -99 |
Bachelor in biologi from University of Copenhagen |
| 1999- 2000 |
Internatinal Study Abroad Programme, Murdoch University, Perth, Australia |
| 2000 –2002 |
Master thesis at Steno Diabetes Center, Gentofte.
Supervisor: Prof., dr.med. Oluf B. Pedersen.
Title:”Genetic and Functional studies of the Insulin Receptor, the Islet amyloid Polypeptide and the Hepatocyte Nuclear Factor-4α: Implications for Abnormalities in Glucose Homeostasis in Humans”. |
| 2001 |
Research project at Prof. Jorge Ferrer, M.D., Ph.D. flab at the Institut d’Investigacions Biomédiques, Barcelona, Spanien |
| 2002 |
Cand. scient. in biologi from University of Copenhagen |
| 2002 –03 |
Post Doc. in ph.d. Jan Fleckners research team, Novo Nordisk, Bagsværd, Denmark |
| Jan 2004- |
Ph.D-student at the Faculty of Health Sciences performed in Professor, chief physician, dr.med Hans-Henrik Parvings reserach team, Steno Diabetes Center, Gentofte.
PhDtitel: “Studies of genetic risk factors associated with development and progression of diabetic kidney disease in Danish type 1 diabetic patients” |
Scientific publications
Hansen SK, Párrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T: Genetic evidence that HNF-1α dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function. J. Clin. Invest 110 (6): 827-833 (2002)
Pildal J., Lajer M., Hansen S. K., Almind K., Ambye L., Borch-Johnsen K., Carstensen B., Hansen T., Pedersen O.: Studies of variability in the islet amyloid polypeptide gene in relation to type 2 diabetes. Diabetic Medicine, (20): 491-494 (2003)
Højlund K, Hansen T, Lajer M, Henriksen JE, Levin K, Lindholm J, Pedersen O, Beck-Nielsen H: A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. Diabetes, 53(6):1592-8, (2004)
E-M.D. Nielsen, L. Hansen, M. Lajer, K.L Andersen, S.M. Echwald, S.A. Urhammer, T. Hansen, O. Pedersen. A common polymorphism in the promoter of the IGF-I gene associates with reduced fasting serum triglyceride levels in glucose tolerant subjects. Clin Biochem., 37(8):660-5, (2004)
Lajer M, Tarnow L, Fleckner J, Hansen BV, Edwards DG, Parving H-H, Boel E. Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients. Diabetic Medicine, 21(8):867-73, (2004)
Lajer M, Schjoedt KJ, Jacobsen P, Tarnow L, Parving H-H.
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients. Diabetic Medicine, 23(6):675-80, (2006)
Schjoedt KJ, Lajer M, Andersen S, Tarnow L, Rossing P, Parving H-H.
Aldosterone synthase (CYP11B2) -344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy. Scand J Clin Lab Invest., 66(3):173-80, (2006)
Ek J, Hansen SP, Lajer M, Nicot C, Boesgaard TW, Pruhova S, Johansen A,
Albrechtsen A, Yderstraede K, Lauenborg J, Parrizas M, Boj SF, Jorgensen T,
Borch-Johnsen K, Damm P, Ferrer J, Lebl J, Pedersen O, Hansen T. A Novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes. Diabetes, 55(6):1869-1873, (2006)
Lajer M, Tarnow L, Andersen S., Parving H-H.
CYP2C9 Variant Modifies Blood Pressure Lowering Response to Losartan in Type 1 Diabetic Patients with Nephropathy, Diabetic Medicine,. 24 (3): 323-325, (2007)
Lajer M, Tarnow L, Jorsal A, Parving H-H
Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients, Nephrology Dialysis Transplantation, (2007) In press
Ph.D- courses
2003
|
Basic statistics for health researchers, University of Copenhagen |
2005
|
Pharmacogenomics, DIRAC (Danish Clinical School for Intervention) |
2005
|
Genetic Epidemiology, University of Copenhagen |
2006
|
Micro array analysis and bioinformatics, DTU |
2006
|
Protein Structure and Computational Biology, DTU |
| 2006 |
The Renin Angiotensin Aldosterone System, DaCRA (Danish Cardiovascular Research Academy) |
|
