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Maria Lajer
Senior Researcher, PhD
| Education |
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| 1995 - 99 |
Bachelor in biologi from University of Copenhagen |
| 1999- 2000 |
Internatinal Study Abroad Programme, Murdoch University, Perth, Australia |
| 2000 –02 |
Master thesis at Steno Diabetes Center, Gentofte.
Supervisor: Prof., dr.med. Oluf Pedersen.
Title:”Genetic and Functional studies of the Insulin Receptor, the Islet amyloid Polypeptide and the Hepatocyte Nuclear Factor-4α: Implications for Abnormalities in Glucose Homeostasis in Humans”. |
| 2001 |
Research project at Prof. Jorge Ferrer, M.D., Ph.D. flab at the Institut d’Investigacions Biomédiques, Barcelona, Spanien |
| 2002 |
Cand. scient. in biologi from University of Copenhagen |
| 2002 –03 |
Post Doc. in ph.d. Jan Fleckners research team, Novo Nordisk, Bagsværd, Denmark |
| Jan 2004- |
Ph.D-student at the Faculty of Health Sciences performed in Professor, chief physician, dr.med Hans-Henrik Parvings reserach team, Steno Diabetes Center, Gentofte.
PhDtitel: “Studies of genetic risk factors associated with development and progression of diabetic kidney disease in Danish type 1 diabetic patients” |
| Scientific publications |
| Hansen SK, Párrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T: Genetic evidence that HNF-1α dependent transcriptional control of HNF-4α is essential for human pancreatic β cell function. J. Clin. Invest 110 (6): 827-833 (2002) |
| Pildal J., Lajer M., Hansen S. K., Almind K., Ambye L., Borch-Johnsen K., Carstensen B., Hansen T., Pedersen O.: Studies of variability in the islet amyloid polypeptide gene in relation to type 2 diabetes. Diabetic Medicine, (20): 491-494 (2003) |
| Højlund K, Hansen T, Lajer M, Henriksen JE, Levin K, Lindholm J, Pedersen O, Beck-Nielsen H: A novel syndrome of autosomal-dominant hyperinsulinemic hypoglycemia linked to a mutation in the human insulin receptor gene. Diabetes, 53(6):1592-8, (2004) |
| E-M.D. Nielsen, L. Hansen, M. Lajer, K.L Andersen, S.M. Echwald, S.A. Urhammer, T. Hansen, O. Pedersen. A common polymorphism in the promoter of the IGF-I gene associates with reduced fasting serum triglyceride levels in glucose tolerant subjects. Clin Biochem., 37(8):660-5, (2004) |
| Lajer M, Tarnow L, Fleckner J, Hansen BV, Edwards DG, Parving H-H, Boel E. Association of aldose reductase gene Z+2 polymorphism with reduced susceptibility to diabetic nephropathy in Caucasian Type 1 diabetic patients. Diabetic Medicine, 21(8):867-73, (2004) |
Lajer M, Schjoedt KJ, Jacobsen P, Tarnow L, Parving H-H.
Aldosterone synthase (CYP11B2) -344T/C polymorphism is not associated with the initiation and progression of diabetic nephropathy in Caucasian Type 1 diabetic patients. Diabetic Medicine, 23(6):675-80, (2006) |
Schjoedt KJ, Lajer M, Andersen S, Tarnow L, Rossing P, Parving H-H.
Aldosterone synthase (CYP11B2) -344T/C polymorphism and renoprotective response to losartan treatment in diabetic nephropathy. Scand J Clin Lab Invest., 66(3):173-80, (2006) |
| Ek J, Hansen SP, Lajer M, Nicot C, Boesgaard TW, Pruhova S, Johansen A,Albrechtsen A, Yderstraede K, Lauenborg J, Parrizas M, Boj SF, Jorgensen T,Borch-Johnsen K, Damm P, Ferrer J, Lebl J, Pedersen O, Hansen T. A Novel -192c/g Mutation in the Proximal P2 Promoter of the Hepatocyte Nuclear Factor-4α Gene (HNF4A) Associates With Late-Onset Diabetes. Diabetes, 55(6):1869-1873, (2006) |
Lajer M, Tarnow L, Andersen S., Parving H-H.
CYP2C9 Variant Modifies Blood Pressure Lowering Response to Losartan in Type 1 Diabetic Patients with Nephropathy, Diabetic Medicine,. 24 (3): 323-325, (2007) |
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Lajer M, Tarnow L, Jorsal A, Parving H-H
Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients, Nephrology Dialysis Transplantation, (2007) In press
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| Ph.D- courses |
| 2003 |
Basic statistics for health researchers, University of Copenhagen |
| 2005 |
Pharmacogenomics, DIRAC (Danish Clinical School for Intervention) |
| 2005 |
Genetic Epidemiology, University of Copenhagen |
| 2006 |
Micro array analysis and bioinformatics, DTU |
| 2006 |
Protein Structure and Computational Biology, DTU |
2006
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The Renin Angiotensin Aldosterone System, DaCRA (Danish Cardiovascular Research Academy) |
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Maria Lajer
Steno Diabetes Center
Niels Steensens Vej 1
DK-2820 Gentofte
Telephone +45 4443 3381
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